LENVIMA dosing and administration
Once a day. Every day. With or without food1
![LENVIMA dosing for RAI-R differentiated thyroid cancer is once a day, every day, with or without food graphic.](/-/media/Project/EIsai/LenvimaHcpRedesign/DTC/Dosing/RAI-R-DTC-with-or-without-food-graphic.png)
![LENVIMA dosing for RAI-R differentiated thyroid cancer is once a day, every day, with or without food graphic mobile](/-/media/Project/EIsai/LenvimaHcpRedesign/DTC/Dosing/RAI-R-DTC-with-or-without-food-graphic-mobile.png)
Recommended LENVIMA dose: 24 mg (two 10-mg capsules and one 4-mg capsule).1
- Place the required number of capsules, up to a maximum of 5, in a small container (approximately 20 mL capacity) or syringe (20 mL). Do not break or crush capsules
- Add 3 mL of liquid to the container or syringe. Wait 10 minutes for the capsule shell (outer surface) to disintegrate, then stir or shake the mixture for 3 minutes until capsules are fully disintegrated and administer the entire contents
- Next, add an additional 2 mL of liquid to the container or syringe using a second syringe or dropper, swirl or shake and administer. Repeat this step at least once and until there is no visible residue to ensure all of the medication is taken
- If 6 capsules are required for a dose, follow these instructions using 3 capsules at a time
Preparation of suspension:
If LENVIMA suspension is not used at the time of preparation, LENVIMA suspension may be stored in a refrigerator at 36°F to 46°F (2°C to 8°C) for a maximum of 24 hours in a covered container. If not administered within 24 hours, the suspension should be discarded.
Note: Compatibility has been confirmed for polypropylene syringes and for feeding tubes of at least 5 French diameter (polyvinyl chloride or polyurethane tube) and at least 6 French diameter (silicone tube).
Dose adjustments for renal or hepatic impairment
Recommended dose of LENVIMA for severe renal or hepatic impairment1
![LENVIMA dosage can be adjusted for severe renal impairment or severe hepatic impairment.](/-/media/Project/EIsai/LenvimaHcpRedesign/DTC/Dosing/RAI-R-DTC-dosage-for-renal-or-hepatic-impairment.png)
![LENVIMA dosage can be adjusted for severe renal impairment or severe hepatic impairment mobile.](/-/media/Project/EIsai/LenvimaHcpRedesign/DTC/Dosing/RAI-R-DTC-dosage-for-renal-or-hepatic-impairment-mobile.png)
No dose adjustment is recommended in patients with mild or moderate renal or hepatic impairment.*
LENVIMA has not been studied in patients with end-stage renal disease.
RAI=radioactive iodine; DTC=differentiated thyroid cancer; CrCl=creatinine clearance.
- *Mild renal impairment is defined as CrCl 60-89 mL/min and moderate renal impairment is defined as CrCl 30-59 mL/min.
- aAs calculated by the Cockcroft-Gault equation.
LENVIMA capsules are supplied in cartons of 6 blister cards. Each carton contains a 30-day supply of LENVIMA capsules
- Continue LENVIMA until disease progression or until unacceptable toxicity
- LENVIMA should be taken at the same time each day. If a patient misses a dose, and it cannot be taken within 12 hours, then that dose should be skipped, and the next dose should be taken at the usual time of administration
- LENVIMA is available as 10-mg and 4-mg capsules
![LENVIMA capsules are supplied in cartons of 6 blister cards, with a 24-mg daily dose taken in 10 mg and 4 mg capsules.](/-/media/Project/EIsai/LenvimaHcpRedesign/DTC/Dosing/RAI-R-DTC-blister-pack-graphic.jpg)
![LENVIMA capsules are supplied in cartons of 6 blister cards, with a 24-mg daily dose taken in 10 mg and 4 mg capsules mobile](/-/media/Project/EIsai/LenvimaHcpRedesign/DTC/Dosing/RAI-R-DTC-blister-pack-graphic-mobile.jpg)
![Eisai Engage logo](/-/media/Project/EIsai/LenvimaHcpRedesign/Common/eisai-engage-logo.png)
Eisai Engage
Connect to HCP services at Eisai Engage to request materials for your practice, contact a sales representative, and more.
Visit Eisai Engage now