SELECT: A phase 3, multicenter, randomized, double-blind, placebo-controlled trial in patients with locally recurrent or metastatic RAI-R DTC1
![Study design for SELECT for LENVIMA in radioactive iodine-refractory differentiated thyroid cancer](/-/media/Project/EIsai/LenvimaHcpRedesign/DTC/Study-Design/RAI-R-DTC-SELECT-study-design-desktop.jpg)
![Study design for SELECT for LENVIMA in radioactive iodine-refractory differentiated thyroid cancer mobile](/-/media/Project/EIsai/LenvimaHcpRedesign/DTC/Study-Design/RAI-R-DTC-SELECT-study-design-mobile.png)
SELECT=Study of (E7080) LEnvatinib in Differentiated Cancer of the Thyroid; RAI-R=radioactive iodine-refractory; DTC=differentiated thyroid cancer; VEGF=vascular endothelial growth factor; VEGFR=vascular endothelial growth factor receptor; PFS=progression-free survival; ORR=objective response rate; OS=overall survival.
aDetermined by blinded, independent radiologic review using Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1.
Baseline patient characteristics2,3
![Baseline patient characteristics in the SELECT trial for RAI-R differentiated thyroid cancer](/-/media/Project/EIsai/LenvimaHcpRedesign/DTC/Study-Design/RAI-R-DTC-baseline-patient-characteristics-desktop.png)
![Baseline patient characteristics in the SELECT trial for RAI-R differentiated thyroid cancer mobile](/-/media/Project/EIsai/LenvimaHcpRedesign/DTC/Study-Design/RAI-R-DTC-baseline-patient-characteristics-mobile.png)
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4 out of 10 patients were >65 years old
The median cumulative RAI activity administered prior to study entry was 350 mCi (12.95 GBq).1
ECOG=Eastern Cooperative Oncology Group; RAl=radioactive iodine; mCi=millicurie; GBq=gigabecquerel.
aHistologic findings were determined from investigators’ reports.