LENVIMA dosing and administration

Once a day. Every day. With or without food¹

Recommended dose: 18 mg LENVIMA (one 10-mg capsule and two 4-mg capsules) + one 5-mg tablet of everolimus.¹

• Continue LENVIMA until disease progression or unacceptable toxicity
• The approved combination contains half of the 10-mg dose that was used in the everolimus monotherapy arm of Study 205. The half-life of LENVIMA is approximately 28 hours
• If a patient misses a dose and it cannot be taken within 12 hours, then that dose should be skipped and the next dose should be taken at the usual time of administration

Preparation of suspension:

• Place the required number of capsules, up to a maximum of 5, in a small container (approximately 20 mL capacity) or syringe (20 mL). Do not break or crush capsules
• Add 3 mL of liquid to the container or syringe. Wait 10 minutes for the capsule shell (outer surface) to disintegrate, then stir or shake the mixture for 3 minutes until capsules are fully disintegrated and administer the entire contents
• Next, add an additional 2 mL of liquid to the container or syringe using a second syringe or dropper, swirl or shake and administer. Repeat this step at least once and until there is no visible residue to ensure all of the medication is taken
• If 6 capsules are required for a dose, follow these instructions using 3 capsules at a time

If LENVIMA suspension is not used at the time of preparation, LENVIMA suspension may be stored in a refrigerator at 36°F to 46°F (2°C to 8°C) for a maximum of 24 hours in a covered container. If not administered within 24 hours, the suspension should be discarded.

Note: Compatibility has been confirmed for polypropylene syringes and for feeding tubes of at least 5 French diameter (polyvinyl chloride or polyurethane tube) and at least 6 French diameter (silicone tube).

Everolimus is not distributed by Eisai Inc.